3k7v: Difference between revisions

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{{Seed}}
[[Image:3k7v.png|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_3k7v", creates the "Structure Box" on the page.
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{{STRUCTURE_3k7v|  PDB=3k7v  |  SCENE=  }}  
{{STRUCTURE_3k7v|  PDB=3k7v  |  SCENE=  }}  
===Protein phosphatase 2A core complex bound to dinophysistoxin-1===
===Protein phosphatase 2A core complex bound to dinophysistoxin-1===
{{ABSTRACT_PUBMED_19916524}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/2AAA_HUMAN 2AAA_HUMAN]] The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.<ref>PMID:16580887</ref>  [[http://www.uniprot.org/uniprot/PP2AA_HUMAN PP2AA_HUMAN]] PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.<ref>PMID:9920888</ref> <ref>PMID:10801873</ref> <ref>PMID:22613722</ref> 
The line below this paragraph, {{ABSTRACT_PUBMED_19916524}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 19916524 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19916524}}


==About this Structure==
==About this Structure==
3K7V is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K7V OCA].  
[[3k7v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K7V OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:19916524</ref><references group="xtra"/>
<ref group="xtra">PMID:019916524</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Phosphoprotein phosphatase]]
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[[Category: Jeffrey, P D.]]
[[Category: Jeffrey, P D.]]
[[Category: Shi, Y.]]
[[Category: Shi, Y.]]
[[Category: Acetylation]]
[[Category: Centromere]]
[[Category: Centromere]]
[[Category: Cytoplasm]]
[[Category: Cytoskeleton]]
[[Category: Cytoskeleton]]
[[Category: Heat repeat]]
[[Category: Heat repeat]]
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[[Category: Phosphatase]]
[[Category: Phosphatase]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Protein phosphatase]]
[[Category: Protein phosphatase]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
 
[[Category: Signaling protein-hydrolase complex]]
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Retrieved from "https://proteopedia.org/3k7v"