3kfc: Difference between revisions

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{{Seed}}
[[Image:3kfc.png|left|200px]]
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{{STRUCTURE_3kfc|  PDB=3kfc  |  SCENE=  }}  
{{STRUCTURE_3kfc|  PDB=3kfc  |  SCENE=  }}  
===Complex Structure of LXR with an agonist===
===Complex Structure of LXR with an agonist===
{{ABSTRACT_PUBMED_19932617}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).  
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{{ABSTRACT_PUBMED_19932617}}


==About this Structure==
==About this Structure==
3KFC is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFC OCA].  
[[3kfc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFC OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:19932617</ref><references group="xtra"/>
<ref group="xtra">PMID:019932617</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bernotas, R C.]]
[[Category: Bernotas, R C.]]
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[[Category: Nuclear receptor]]
[[Category: Nuclear receptor]]
[[Category: Nucleus]]
[[Category: Nucleus]]
[[Category: Polymorphism]]
[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:37:07 2010''

Revision as of 02:15, 4 April 2013

Template:STRUCTURE 3kfc

Complex Structure of LXR with an agonist

Template:ABSTRACT PUBMED 19932617

Function

[NR1H2_HUMAN] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).

About this Structure

3kfc is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Bernotas RC, Singhaus RR, Kaufman DH, Travins JM, Ullrich JW, Unwalla R, Quinet E, Evans M, Nambi P, Olland A, Kauppi B, Wilhelmsson A, Goos-Nilsson A, Wrobel J. 4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists. Bioorg Med Chem Lett. 2010 Jan 1;20(1):209-12. Epub 2009 Oct 31. PMID:19932617 doi:10.1016/j.bmcl.2009.10.132

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