3kb5: Difference between revisions

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===PRY-SPRY domain of human TRIM72===

==Function==

[[http://www.uniprot.org/uniprot/TRI72_HUMAN TRI72_HUMAN]] Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).

==About this Structure==

~~3KB5~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KB5 OCA].

[[3kb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KB5 OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Jeong, B C.]]

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[[Category: Gustavus]]

[[Category: High resolution]]

[[Category: Membrane protein]]

[[Category: Mg53]]

[[Category: Pry]]

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[[Category: Trim72]]

[[Category: Tripartite motif]]

~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 09:56:34 2009''~~

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-{{Seed}}
-[[Image:3kb5.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3kb5", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3kb5|  PDB=3kb5  |  SCENE=  }}
 ===PRY-SPRY domain of human TRIM72===
+==Function==
+[[http://www.uniprot.org/uniprot/TRI72_HUMAN TRI72_HUMAN]] Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
 ==About this Structure==
-KB5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KB5 OCA].
+[[3kb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KB5 OCA].
 ==Reference==
-<ref group="xtra">PMID:19967786</ref><references group="xtra"/>
+<ref group="xtra">PMID:019967786</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Jeong, B C.]]
@@ Line 26: / Line 18: @@
 [[Category: Gustavus]]
 [[Category: High resolution]]
+[[Category: Membrane protein]]
 [[Category: Mg53]]
 [[Category: Pry]]
@@ Line 32: / Line 25: @@
 [[Category: Trim72]]
 [[Category: Tripartite motif]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 09:56:34 2009''