3k2z: Difference between revisions
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{{STRUCTURE_3k2z| PDB=3k2z | SCENE= }} | {{STRUCTURE_3k2z| PDB=3k2z | SCENE= }} | ||
===Crystal structure of a LexA protein from Thermotoga maritima=== | ===Crystal structure of a LexA protein from Thermotoga maritima=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/LEXA_THEMA LEXA_THEMA]] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[3k2z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K2Z OCA]. | |||
[[Category: Repressor lexA]] | [[Category: Repressor lexA]] | ||
[[Category: Thermotoga maritima]] | [[Category: Thermotoga maritima]] | ||
| Line 32: | Line 24: | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
[[Category: Winged helix-turn-helix]] | [[Category: Winged helix-turn-helix]] | ||
Revision as of 02:27, 4 April 2013
Crystal structure of a LexA protein from Thermotoga maritima
Function
[LEXA_THEMA] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity).
About this Structure
3k2z is a 2 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
