2l5d: Difference between revisions

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~~[[Image:2l5d.png|left|200px]]~~

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===Solution Structures of human PIWI-like 1 PAZ domain with ssRNA (5'-pUGACA)===

==Function==

[[http://www.uniprot.org/uniprot/PIWL1_HUMAN PIWL1_HUMAN]] Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator.<ref>PMID:12037681</ref> <ref>PMID:14749716</ref> <ref>PMID:16287078</ref>

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Yan, K.]]

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[[Category: Zhang, Q.]]

[[Category: Zhou, M.]]

[[Category: Paz]]

[[Category: Pirna]]

[[Category: Piwi]]

[[Category: Rna binding protein-rna complex]]

[[Category: Ssrna]]

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-[[Image:2l5d.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_2l5d", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_2l5d|  PDB=2l5d  |  SCENE=  }}
 ===Solution Structures of human PIWI-like 1 PAZ domain with ssRNA (5'-pUGACA)===
+==Function==
+[[http://www.uniprot.org/uniprot/PIWL1_HUMAN PIWL1_HUMAN]] Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator.<ref>PMID:12037681</ref> <ref>PMID:14749716</ref> <ref>PMID:16287078</ref>
 ==About this Structure==
@@ Line 16: / Line 9: @@
 ==Reference==
-<ref group="xtra">PMID:021465557</ref><references group="xtra"/>
+<ref group="xtra">PMID:021465557</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Yan, K.]]
@@ Line 22: / Line 15: @@
 [[Category: Zhang, Q.]]
 [[Category: Zhou, M.]]
+[[Category: Paz]]
+[[Category: Pirna]]
+[[Category: Piwi]]
+[[Category: Rna binding protein-rna complex]]
+[[Category: Ssrna]]