3kjo: Difference between revisions

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~~[[Image:3kjo.png|left|200px]]~~

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===Crystal Structure of hPOT1V2-dTrUd(AGGGTTAG)===

==Function==

~~<!--~~

[[http://www.uniprot.org/uniprot/POTE1_HUMAN POTE1_HUMAN]] Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.<ref>PMID:12781132</ref> <ref>PMID:12768206</ref> <ref>PMID:16166375</ref> <ref>PMID:17237768</ref> <ref>PMID:20231318</ref>

~~The line below this paragraph, {{ABSTRACT_PUBMED_20080730}}, adds the Publication Abstract to the page~~

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 20080730 is~~ the ~~PubMed ID number~~.

-->

~~{{ABSTRACT_PUBMED_20080730}}~~

==About this Structure==

~~3KJO~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJO OCA].

[[3kjo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJO OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Cech, T R.]]

[[Category: Nandakumar, J.]]

[[Category: Podell, E R.]]

~~[[Category: Alternative splicing]]~~

[[Category: Chromosomal protein]]

[[Category: Dna binding protein-dna complex]]

[[Category: Dna-binding]]

[[Category: Nucleus]]

[[Category: Ob domain]]

~~[[Category: Polymorphism]]~~

[[Category: Protein-dna complex]]

[[Category: Protein-rna complex]]

[[Category: Telomere]]

~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 09:02:07 2010''~~

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@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:3kjo.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3kjo", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3kjo|  PDB=3kjo  |  SCENE=  }}
 ===Crystal Structure of hPOT1V2-dTrUd(AGGGTTAG)===
+{{ABSTRACT_PUBMED_20080730}}
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/POTE1_HUMAN POTE1_HUMAN]] Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.<ref>PMID:12781132</ref> <ref>PMID:12768206</ref> <ref>PMID:16166375</ref> <ref>PMID:17237768</ref> <ref>PMID:20231318</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_20080730}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 20080730 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_20080730}}
 ==About this Structure==
-KJO is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJO OCA].
+[[3kjo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJO OCA].
 ==Reference==
-<ref group="xtra">PMID:20080730</ref><references group="xtra"/>
+<ref group="xtra">PMID:020080730</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Cech, T R.]]
 [[Category: Nandakumar, J.]]
 [[Category: Podell, E R.]]
-[[Category: Alternative splicing]]
 [[Category: Chromosomal protein]]
+[[Category: Dna binding protein-dna complex]]
 [[Category: Dna-binding]]
 [[Category: Nucleus]]
 [[Category: Ob domain]]
-[[Category: Polymorphism]]
 [[Category: Protein-dna complex]]
 [[Category: Protein-rna complex]]
 [[Category: Telomere]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb  3 09:02:07 2010''