3khb: Difference between revisions

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{{Seed}}
[[Image:3khb.png|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3khb", creates the "Structure Box" on the page.
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{{STRUCTURE_3khb|  PDB=3khb  |  SCENE=  }}  
{{STRUCTURE_3khb|  PDB=3khb  |  SCENE=  }}  
===Crystal structure of Escherichia coli AlkB with Co(II) and 2-OG===
===Crystal structure of Escherichia coli AlkB with Co(II) and 2-OG===
{{ABSTRACT_PUBMED_20084272}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/ALKB_ECOLI ALKB_ECOLI]] Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents).<ref>PMID:12226668</ref> <ref>PMID:12594517</ref> <ref>PMID:16482161</ref> <ref>PMID:19706517</ref> <ref>PMID:21068844</ref> <ref>PMID:20084272</ref> 
The line below this paragraph, {{ABSTRACT_PUBMED_20084272}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 20084272 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20084272}}


==About this Structure==
==About this Structure==
3KHB is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KHB OCA].  
[[3khb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KHB OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20084272</ref><references group="xtra"/>
<ref group="xtra">PMID:020084272</ref><references group="xtra"/><references/>
[[Category: Escherichia coli k-12]]
[[Category: Escherichia coli k-12]]
[[Category: Holland, P J.]]
[[Category: Holland, P J.]]
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[[Category: Metal-binding]]
[[Category: Metal-binding]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb  3 09:06:23 2010''
Retrieved from "https://proteopedia.org/3khb"