2e2b: Difference between revisions

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==Overview==

To investigate why 3-substituted benzamide derivatives show dual, inhibition of Abl and Lyn protein tyrosine kinases, we determined their, inhibitory activities against Abl and Lyn, carried out molecular modeling, and conducted a structure-activity relationship study with the aid of a, newly determined X-ray structure of the Abl/Lyn dual inhibitor INNO-406, (formerly known as NS-187) bound to human Abl. We found that this series, of compounds interacted with both kinases in very similar ways, so that, they can inhibit both kinases effectively.

To investigate why 3-substituted benzamide derivatives show dual inhibition of Abl and Lyn protein tyrosine kinases, we determined their inhibitory activities against Abl and Lyn, carried out molecular modeling, and conducted a structure-activity relationship study with the aid of a newly determined X-ray structure of the Abl/Lyn dual inhibitor INNO-406 (formerly known as NS-187) bound to human Abl. We found that this series of compounds interacted with both kinases in very similar ways, so that they can inhibit both kinases effectively.

==Disease==

Known diseases associated with this structure: Leukemia, Philadelphia chromosome-positive, resistant to imatinib OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=189980 189980]]

==About this Structure==

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[[Category: kinase]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:05:11 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-To investigate why 3-substituted benzamide derivatives show dual, inhibition of Abl and Lyn protein tyrosine kinases, we determined their, inhibitory activities against Abl and Lyn, carried out molecular modeling, and conducted a structure-activity relationship study with the aid of a, newly determined X-ray structure of the Abl/Lyn dual inhibitor INNO-406, (formerly known as NS-187) bound to human Abl. We found that this series, of compounds interacted with both kinases in very similar ways, so that, they can inhibit both kinases effectively.
+To investigate why 3-substituted benzamide derivatives show dual inhibition of Abl and Lyn protein tyrosine kinases, we determined their inhibitory activities against Abl and Lyn, carried out molecular modeling, and conducted a structure-activity relationship study with the aid of a newly determined X-ray structure of the Abl/Lyn dual inhibitor INNO-406 (formerly known as NS-187) bound to human Abl. We found that this series of compounds interacted with both kinases in very similar ways, so that they can inhibit both kinases effectively.
+==Disease==
+Known diseases associated with this structure: Leukemia, Philadelphia chromosome-positive, resistant to imatinib OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=189980 189980]]
 ==About this Structure==
@@ Line 24: / Line 27: @@
 [[Category: kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:10:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:05:11 2008''