3l0m: Difference between revisions

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{{Seed}}
[[Image:3l0m.png|left|200px]]
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{{STRUCTURE_3l0m|  PDB=3l0m  |  SCENE=  }}  
{{STRUCTURE_3l0m|  PDB=3l0m  |  SCENE=  }}  
===Crystal structure of Rab1-activation domain and P4M domain of SidM/DrrA from legionella===
===Crystal structure of Rab1-activation domain and P4M domain of SidM/DrrA from legionella===
{{ABSTRACT_PUBMED_20176951}}


 
==Function==
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[[http://www.uniprot.org/uniprot/Q29ST3_LEGPN Q29ST3_LEGPN]] Virulence effector that plays a key role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a GDP-GTP exchange factor (GEF) for the small GTPase Rab1 (RAB1A, RAB1B or RAB1C), thereby converting Rab1 to an active GTP-bound state, leading to the incorporation of Rab1 into LCVs. Also shows RabGDI displacement factor (GDF) activity; however, this probably represents a passive activity following the GEF activity. Also acts as an adenylyltransferase by mediating the addition of adenosine 5'-monophosphate (AMP) to 'Tyr-77' of host RAB1B, thereby rendering RAB1B constitutively active. Also has adenylyltransferase activity towards Rab6 and Rab35. Also displays guanylyltransferase activity by mediating the addition of guanosine 5'-monophosphate (GMP) to host RAB1B in vitro; however such activity remains uncertain in vivo. Specifically binds phosphatidylinositol 4-phosphate (PtdIns(4)P) lipids on the cytosolic surface of the phagosomal membrane shortly after infection.<ref>PMID:16906144</ref> <ref>PMID:17952054</ref> <ref>PMID:20651120</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_20176951}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_20176951}}


==About this Structure==
==About this Structure==
3L0M is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0M OCA].  
[[3l0m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0M OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20176951</ref><references group="xtra"/>
<ref group="xtra">PMID:020176951</ref><references group="xtra"/><references/>
[[Category: Legionella pneumophila]]
[[Category: Legionella pneumophila]]
[[Category: Shao, F.]]
[[Category: Shao, F.]]
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[[Category: Gef/gdf of rab1]]
[[Category: Gef/gdf of rab1]]
[[Category: Protein binding]]
[[Category: Protein binding]]
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