3kur: Difference between revisions

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{{Seed}}
[[Image:3kur.png|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3kur", creates the "Structure Box" on the page.
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{{STRUCTURE_3kur|  PDB=3kur  |  SCENE=  }}  
{{STRUCTURE_3kur|  PDB=3kur  |  SCENE=  }}  
===Crystal structure of the MLLE domain of poly(A)-binding protein===
===Crystal structure of the MLLE domain of poly(A)-binding protein===
{{ABSTRACT_PUBMED_20096703}}


 
==Function==
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[[http://www.uniprot.org/uniprot/PABP1_HUMAN PABP1_HUMAN]] Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.<ref>PMID:11051545</ref> <ref>PMID:18447585</ref> 
The line below this paragraph, {{ABSTRACT_PUBMED_20096703}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_20096703}}


==About this Structure==
==About this Structure==
3KUR is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUR OCA].  
[[3kur]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUR OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20096703</ref><references group="xtra"/>
<ref group="xtra">PMID:020096703</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Gehring, K.]]
[[Category: Gehring, K.]]
[[Category: Kozlov, G.]]
[[Category: Kozlov, G.]]
[[Category: Acetylation]]
[[Category: All-helical domain]]
[[Category: All-helical domain]]
[[Category: Alternative splicing]]
[[Category: Cytoplasm]]
[[Category: Methylation]]
[[Category: Methylation]]
[[Category: Mrna processing]]
[[Category: Mrna processing]]
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[[Category: Rna-binding]]
[[Category: Rna-binding]]
[[Category: Spliceosome]]
[[Category: Spliceosome]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:22:07 2010''
Retrieved from "https://proteopedia.org/3kur"