3l4h: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3l4h| PDB=3l4h | SCENE= }} | {{STRUCTURE_3l4h| PDB=3l4h | SCENE= }} | ||
===Helical box domain and second WW domain of the human E3 ubiquitin-protein ligase HECW1=== | ===Helical box domain and second WW domain of the human E3 ubiquitin-protein ligase HECW1=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/HECW1_HUMAN HECW1_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. | |||
==About this Structure== | ==About this Structure== | ||
[[3l4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L4H OCA]. | |||
==See Also== | |||
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
| Line 26: | Line 21: | ||
[[Category: Walker, J R.]] | [[Category: Walker, J R.]] | ||
[[Category: Weigelt, J.]] | [[Category: Weigelt, J.]] | ||
[[Category: E3 ligase]] | [[Category: E3 ligase]] | ||
[[Category: Helical box domain]] | [[Category: Helical box domain]] | ||
| Line 37: | Line 30: | ||
[[Category: Ubl-conjugation pathway]] | [[Category: Ubl-conjugation pathway]] | ||
[[Category: Ww domain]] | [[Category: Ww domain]] | ||
Revision as of 20:00, 4 April 2013
Helical box domain and second WW domain of the human E3 ubiquitin-protein ligase HECW1
Function
[HECW1_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
About this Structure
3l4h is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
