3kze: Difference between revisions
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{{STRUCTURE_3kze| PDB=3kze | SCENE= }} | {{STRUCTURE_3kze| PDB=3kze | SCENE= }} | ||
===Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in Complex With SSRKEYYA Peptide=== | ===Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in Complex With SSRKEYYA Peptide=== | ||
{{ABSTRACT_PUBMED_20361982}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TIAM1_HUMAN TIAM1_HUMAN]] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. | |||
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020361982</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Fuentes, E J.]] | [[Category: Fuentes, E J.]] | ||
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[[Category: Pdz]] | [[Category: Pdz]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
[[Category: Tiam1]] | [[Category: Tiam1]] | ||
Revision as of 20:03, 4 April 2013
Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in Complex With SSRKEYYA Peptide
Template:ABSTRACT PUBMED 20361982
Function
[TIAM1_HUMAN] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
About this Structure
3kze is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ. The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. J Mol Biol. 2010 May 21;398(5):730-46. Epub 2010 Mar 31. PMID:20361982 doi:10.1016/j.jmb.2010.03.047
