3l4c: Difference between revisions
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Revision as of 20:07, 4 April 2013
Structural basis of membrane-targeting by Dock180
Template:ABSTRACT PUBMED 20167601
Function
[DOCK1_HUMAN] Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.[1]
About this Structure
3l4c is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Premkumar L, Bobkov AA, Patel M, Jaroszewski L, Bankston LA, Stec B, Vuori K, Cote JF, Liddington RC. Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs). J Biol Chem. 2010 Apr 23;285(17):13211-22. Epub 2010 Feb 18. PMID:20167601 doi:10.1074/jbc.M110.102517
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Bankston, L A.
- Bobkov, A A.
- Cote, J-.F.
- Jaroszewski, L.
- Liddington, R C.
- Patel, M.
- Premkumar, L.
- Stec, B.
- Vuori, K.
- Apoptosis
- Cell adhesion
- Cell invasion
- Cell migration
- Cell polarity
- Cytoskeleton
- Dock1
- Dock180
- Guanine exchange factor
- Guanine-nucleotide releasing factor
- Membrane
- Phagocytosis
- Phosphoinositide specificity
- Phosphoprotein
- Rho gtpase
- Sh3 domain
- Sh3-binding
