3kui: Difference between revisions

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{{Seed}}
[[Image:3kui.jpg|left|200px]]
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{{STRUCTURE_3kui|  PDB=3kui  |  SCENE=  }}  
{{STRUCTURE_3kui|  PDB=3kui  |  SCENE=  }}  
===Crystal structure of C-terminal domain of PABPC1 in complex with binding region of eRF3a===
===Crystal structure of C-terminal domain of PABPC1 in complex with binding region of eRF3a===
{{ABSTRACT_PUBMED_20418951}}


 
==Function==
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[[http://www.uniprot.org/uniprot/PABP1_HUMAN PABP1_HUMAN]] Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.<ref>PMID:11051545</ref> <ref>PMID:18447585</ref>  [[http://www.uniprot.org/uniprot/Q96GF2_HUMAN Q96GF2_HUMAN]] Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
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{{ABSTRACT_PUBMED_20418951}}


==About this Structure==
==About this Structure==
3KUI is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUI OCA].  
[[3kui]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUI OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20418951</ref><references group="xtra"/>
<ref group="xtra">PMID:020418951</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Gehring, K.]]
[[Category: Gehring, K.]]
[[Category: Kozlov, G.]]
[[Category: Kozlov, G.]]
[[Category: Acetylation]]
[[Category: Alternative splicing]]
[[Category: Cytoplasm]]
[[Category: Gtp-binding]]
[[Category: Gtp-binding]]
[[Category: Methylation]]
[[Category: Methylation]]
Line 41: Line 25:
[[Category: Rna-binding]]
[[Category: Rna-binding]]
[[Category: Spliceosome]]
[[Category: Spliceosome]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 11:05:53 2010''
Retrieved from "https://proteopedia.org/3kui"