3l1p: Difference between revisions

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{{Seed}}
[[Image:3l1p.jpg|left|200px]]
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{{STRUCTURE_3l1p|  PDB=3l1p  |  SCENE=  }}  
{{STRUCTURE_3l1p|  PDB=3l1p  |  SCENE=  }}  
===POU protein:DNA complex===
===POU protein:DNA complex===


==Function==
[[http://www.uniprot.org/uniprot/PO5F1_MOUSE PO5F1_MOUSE]] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.<ref>PMID:17496161</ref> <ref>PMID:17525163</ref> 


==About this Structure==
==About this Structure==
3L1P is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1P OCA].  
[[3l1p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1P OCA].  
 
==Reference==
<references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Groves, M R.]]
[[Category: Groves, M R.]]
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[[Category: Transcription factor dna complex]]
[[Category: Transcription factor dna complex]]
[[Category: Transcription-dna complex]]
[[Category: Transcription-dna complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:40:47 2010''

Revision as of 20:14, 4 April 2013

Template:STRUCTURE 3l1p

POU protein:DNA complex

Function

[PO5F1_MOUSE] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.[1] [2]

About this Structure

3l1p is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Zhang Z, Liao B, Xu M, Jin Y. Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1. FASEB J. 2007 Oct;21(12):3042-51. Epub 2007 May 11. PMID:17496161 doi:fj.06-6914com
  2. ↑ Wei F, Scholer HR, Atchison ML. Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation. J Biol Chem. 2007 Jul 20;282(29):21551-60. Epub 2007 May 24. PMID:17525163 doi:M611041200

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