3l94: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "3l94" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3l94| PDB=3l94 | SCENE= }} | {{STRUCTURE_3l94| PDB=3l94 | SCENE= }} | ||
===Structure of PvdQ covalently acylated with myristate=== | ===Structure of PvdQ covalently acylated with myristate=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE]] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3l94]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L94 OCA]. | [[3l94]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L94 OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Acyl-homoserine-lactone acylase]] | [[Category: Acyl-homoserine-lactone acylase]] | ||
[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
[[Category: Drake, E J.]] | [[Category: Drake, E J.]] | ||
[[Category: Gulick, A M.]] | [[Category: Gulick, A M.]] | ||
[[Category: Acylase]] | |||
[[Category: Hydrolase]] | |||
[[Category: Ntn hydrolase]] | |||
[[Category: Pvdq]] | |||
[[Category: Pyoverdine]] | |||
[[Category: Quorum sensing]] | |||
[[Category: Zymogen]] | |||