3l51: Difference between revisions
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Revision as of 20:28, 4 April 2013
Crystal Structure of the Mouse Condensin Hinge Domain
Template:ABSTRACT PUBMED 20139420
Function
[SMC2_MOUSE] Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). [SMC4_MOUSE] Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity).
About this Structure
3l51 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Griese JJ, Witte G, Hopfner KP. Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins. Nucleic Acids Res. 2010 Jun;38(10):3454-65. Epub 2010 Feb 5. PMID:20139420 doi:10.1093/nar/gkq038
