3lju: Difference between revisions
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{{STRUCTURE_3lju| PDB=3lju | SCENE= }} | {{STRUCTURE_3lju| PDB=3lju | SCENE= }} | ||
===Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3=== | ===Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3=== | ||
{{ABSTRACT_PUBMED_21057110}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ADAP1_HUMAN ADAP1_HUMAN]] GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).<ref>PMID:10448098</ref> <ref>PMID:10333475</ref> | |||
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==About this Structure== | ==About this Structure== | ||
[[3lju]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LJU OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:021057110</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
| Line 45: | Line 32: | ||
[[Category: Structural genomics consortium]] | [[Category: Structural genomics consortium]] | ||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
Revision as of 20:36, 4 April 2013
Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3
Template:ABSTRACT PUBMED 21057110
Function
[ADAP1_HUMAN] GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).[1] [2]
About this Structure
3lju is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Tong Y, Tempel W, Wang H, Yamada K, Shen L, Senisterra GA, Mackenzie F, Chishti AH, Park HW. Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin {alpha}1. Proc Natl Acad Sci U S A. 2010 Nov 5. PMID:21057110 doi:10.1073/pnas.1009008107
- ↑ Venkateswarlu K, Cullen PJ. Molecular cloning and functional characterization of a human homologue of centaurin-alpha. Biochem Biophys Res Commun. 1999 Aug 19;262(1):237-44. PMID:10448098 doi:10.1006/bbrc.1999.1065
- ↑ Venkateswarlu K, Oatey PB, Tavare JM, Jackson TR, Cullen PJ. Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1. Biochem J. 1999 Jun 1;340 ( Pt 2):359-63. PMID:10333475
