3l2o: Difference between revisions

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{{Seed}}
[[Image:3l2o.png|left|200px]]
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{{STRUCTURE_3l2o|  PDB=3l2o  |  SCENE=  }}  
{{STRUCTURE_3l2o|  PDB=3l2o  |  SCENE=  }}  
===Structure-Based Mechanism of Dimerization-Dependent Ubiquitination by the SCFFbx4 Ubiquitin Ligase===
===Structure-Based Mechanism of Dimerization-Dependent Ubiquitination by the SCFFbx4 Ubiquitin Ligase===
{{ABSTRACT_PUBMED_20181953}}


 
==Function==
<!--  
[[http://www.uniprot.org/uniprot/SKP1_HUMAN SKP1_HUMAN]] Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.<ref>PMID:16209941</ref> <ref>PMID:20181953</ref>  [[http://www.uniprot.org/uniprot/FBX4_HUMAN FBX4_HUMAN]] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.<ref>PMID:10531035</ref> <ref>PMID:16275645</ref> <ref>PMID:18598945</ref> <ref>PMID:20159592</ref> <ref>PMID:20181953</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_20181953}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_20181953}}


==About this Structure==
==About this Structure==
3L2O is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L2O OCA].  
[[3l2o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L2O OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20181953</ref><references group="xtra"/>
<ref group="xtra">PMID:020181953</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hao, B.]]
[[Category: Hao, B.]]
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[[Category: Ubiquitin protein ligase]]
[[Category: Ubiquitin protein ligase]]
[[Category: Ubl conjugation pathway]]
[[Category: Ubl conjugation pathway]]
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