3l82: Difference between revisions

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{{Seed}}
[[Image:3l82.jpg|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3l82", creates the "Structure Box" on the page.
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{{STRUCTURE_3l82|  PDB=3l82  |  SCENE=  }}  
{{STRUCTURE_3l82|  PDB=3l82  |  SCENE=  }}  
===X-ray Crystal structure of TRF1 and Fbx4 complex===
===X-ray Crystal structure of TRF1 and Fbx4 complex===
{{ABSTRACT_PUBMED_20159592}}


 
==Function==
<!--  
[[http://www.uniprot.org/uniprot/TERF1_HUMAN TERF1_HUMAN]] Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.<ref>PMID:16166375</ref>  [[http://www.uniprot.org/uniprot/FBX4_HUMAN FBX4_HUMAN]] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.<ref>PMID:10531035</ref> <ref>PMID:16275645</ref> <ref>PMID:18598945</ref> <ref>PMID:20159592</ref> <ref>PMID:20181953</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_20159592}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 20159592 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20159592}}


==About this Structure==
==About this Structure==
3L82 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L82 OCA].  
[[3l82]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L82 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20159592</ref><references group="xtra"/>
<ref group="xtra">PMID:020159592</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chen, Y.]]
[[Category: Chen, Y.]]
Line 33: Line 20:
[[Category: Yang, Y T.]]
[[Category: Yang, Y T.]]
[[Category: Zeng, Z X.]]
[[Category: Zeng, Z X.]]
[[Category: Acetylation]]
[[Category: Adp-ribosylation]]
[[Category: Adp-ribosylation]]
[[Category: Alternative splicing]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]
[[Category: Cell division]]
[[Category: Cell division]]
[[Category: Chromosomal protein]]
[[Category: Chromosomal protein]]
[[Category: Cytoplasm]]
[[Category: Cytoskeleton]]
[[Category: Cytoskeleton]]
[[Category: Dna-binding]]
[[Category: Dna-binding]]
Line 50: Line 34:
[[Category: Trfh domain]]
[[Category: Trfh domain]]
[[Category: Ubl conjugation pathway]]
[[Category: Ubl conjugation pathway]]
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Retrieved from "https://proteopedia.org/3l82"