3l1y: Difference between revisions

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{{Seed}}
[[Image:3l1y.png|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3l1y", creates the "Structure Box" on the page.
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{{STRUCTURE_3l1y|  PDB=3l1y  |  SCENE=  }}  
{{STRUCTURE_3l1y|  PDB=3l1y  |  SCENE=  }}  
===Crystal structure of human UBC4 E2 conjugating enzyme===
===Crystal structure of human UBC4 E2 conjugating enzyme===
{{ABSTRACT_PUBMED_20696396}}


 
==Function==
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[[http://www.uniprot.org/uniprot/UB2D2_HUMAN UB2D2_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.<ref>PMID:10329681</ref> <ref>PMID:15280377</ref> <ref>PMID:18042044</ref> <ref>PMID:18703417</ref> <ref>PMID:18359941</ref> <ref>PMID:19854139</ref> <ref>PMID:20403326</ref> <ref>PMID:20061386</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_20696396}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 20696396 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20696396}}


==About this Structure==
==About this Structure==
3L1Y is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1Y OCA].  
[[3l1y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1Y OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20696396</ref><references group="xtra"/>
<ref group="xtra">PMID:020696396</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ubiquitin--protein ligase]]
[[Category: Ubiquitin--protein ligase]]
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[[Category: Ubiquitin ligase]]
[[Category: Ubiquitin ligase]]
[[Category: Ubl conjugation pathway]]
[[Category: Ubl conjugation pathway]]
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Retrieved from "https://proteopedia.org/3l1y"