4gml: Difference between revisions
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{{STRUCTURE_4gml| PDB=4gml | SCENE= }} | {{STRUCTURE_4gml| PDB=4gml | SCENE= }} | ||
===Crystal structure of human NOT1 MIF4G domain=== | ===Crystal structure of human NOT1 MIF4G domain=== | ||
{{ABSTRACT_PUBMED_22977175}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN]] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.<ref>PMID:10637334</ref> <ref>PMID:16778766</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4gml]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GML OCA]. | [[4gml]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GML OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Izaurralde, E]] | [[Category: Izaurralde, E.]] | ||
[[Category: Petit, P]] | [[Category: Petit, P.]] | ||
[[Category: Weichenrieder, O]] | [[Category: Weichenrieder, O.]] | ||
[[Category: Wohlbold, L]] | [[Category: Wohlbold, L.]] | ||
[[Category: Ccr4-not]] | [[Category: Ccr4-not]] | ||
[[Category: Deadenylase]] | [[Category: Deadenylase]] | ||
Revision as of 21:40, 10 April 2013
Crystal structure of human NOT1 MIF4G domain
Template:ABSTRACT PUBMED 22977175
Function
[CNOT1_HUMAN] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.[1] [2]
About this Structure
4gml is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. Nucleic Acids Res. 2000 Feb 1;28(3):809-17. PMID:10637334
- ↑ Winkler GS, Mulder KW, Bardwell VJ, Kalkhoven E, Timmers HT. Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription. EMBO J. 2006 Jul 12;25(13):3089-99. Epub 2006 Jun 15. PMID:16778766 doi:7601194
