4eo7: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the TIR domain of human myeloid differentiation primary response protein 88.===

~~The~~ entry ~~4eo7 is ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[http://omim.org/entry/612260 612260]]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref>

~~Authors~~: ~~Snyder, G~~.A., ~~Cirl~~, C., ~~Jiang~~, J.S.~~, Chen, P~~., ~~Smith~~, ~~T., Xiao, T.S~~.

==Function==

[[http://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref> <ref>PMID:15361868</ref> <ref>PMID:18292575</ref> <ref>PMID:19506249</ref>

~~Description~~: ~~Crystal structure of the TIR~~ domain ~~of human myeloid differentiation primary response protein 88.~~

==About this Structure==

[[4eo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EO7 OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Chen, P.]]

[[Category: Cirl, C.]]

[[Category: Jiang, J S.]]

[[Category: Smith, T.]]

[[Category: Snyder, G A.]]

[[Category: Xiao, T S.]]

[[Category: Adapter protein]]

[[Category: Beta-alpha-beta fold]]

[[Category: Innate immune signaling]]

[[Category: Parallel beta sheet]]

[[Category: Protein binding]]

[[Category: Signaling protein]]

[[Category: Tir-domain]]

[[Category: Tirap/mal]]

[[Category: Toll like receptor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4eo7|  PDB=4eo7  |  SCENE=  }}
+===Crystal structure of the TIR domain of human myeloid differentiation primary response protein 88.===
-The entry 4eo7 is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[http://omim.org/entry/612260 612260]]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref>
-Authors: Snyder, G.A., Cirl, C., Jiang, J.S., Chen, P., Smith, T., Xiao, T.S.
+==Function==
+[[http://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref> <ref>PMID:15361868</ref> <ref>PMID:18292575</ref> <ref>PMID:19506249</ref>
-Description: Crystal structure of the TIR domain of human myeloid differentiation primary response protein 88.
+==About this Structure==
+[[4eo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EO7 OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Chen, P.]]
+[[Category: Cirl, C.]]
+[[Category: Jiang, J S.]]
+[[Category: Smith, T.]]
+[[Category: Snyder, G A.]]
+[[Category: Xiao, T S.]]
+[[Category: Adapter protein]]
+[[Category: Beta-alpha-beta fold]]
+[[Category: Innate immune signaling]]
+[[Category: Parallel beta sheet]]
+[[Category: Protein binding]]
+[[Category: Signaling protein]]
+[[Category: Tir-domain]]
+[[Category: Tirap/mal]]
+[[Category: Toll like receptor]]