4gn8: Difference between revisions
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{{STRUCTURE_4gn8| PDB=4gn8 | SCENE= }} | |||
===mouse SMP30/GNL-1,5-AG complex=== | |||
{{ABSTRACT_PUBMED_23349732}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RGN_MOUSE RGN_MOUSE]] Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).<ref>PMID:16585534</ref> | |||
==About this Structure== | |||
[[4gn8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GN8 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Gluconolactonase]] | |||
[[Category: Mus musculus]] | |||
[[Category: Aigaki, T.]] | |||
[[Category: Aizawa, S.]] | |||
[[Category: Harada, A.]] | |||
[[Category: Ishida, T.]] | |||
[[Category: Ishigami, A.]] | |||
[[Category: Maruyama, N.]] | |||
[[Category: Senda, M.]] | |||
[[Category: Senda, T.]] | |||
[[Category: Beta propeller structure]] | |||
[[Category: Hydrolase]] | |||
Revision as of 22:43, 10 April 2013
mouse SMP30/GNL-1,5-AG complex
Template:ABSTRACT PUBMED 23349732
Function
[RGN_MOUSE] Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).[1]
About this Structure
4gn8 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- ↑ Kondo Y, Inai Y, Sato Y, Handa S, Kubo S, Shimokado K, Goto S, Nishikimi M, Maruyama N, Ishigami A. Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5723-8. Epub 2006 Apr 3. PMID:16585534 doi:10.1073/pnas.0511225103
