4jep: Difference between revisions
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{{STRUCTURE_4jep| PDB=4jep | SCENE= }} | |||
===Crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 (NTPDase1)=== | |||
{{ABSTRACT_PUBMED_23526564}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/NTP2_TOXGO NTP2_TOXGO]] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite. NTPAse-II has a specific activity 4.5-fold lower than NTPAse-I in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP). | |||
==About this Structure== | |||
[[4jep]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JEP OCA]. | |||
[[Category: Nucleoside-triphosphatase]] | |||
[[Category: Toxoplasma gondii]] | |||
[[Category: Krug, U.]] | |||
[[Category: Strater, N.]] | |||
[[Category: Totzauer, R.]] | |||
[[Category: Hydrolase]] | |||
[[Category: Phosphatase]] | |||
Revision as of 22:50, 10 April 2013
Crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 (NTPDase1)
Template:ABSTRACT PUBMED 23526564
Function
[NTP2_TOXGO] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite. NTPAse-II has a specific activity 4.5-fold lower than NTPAse-I in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).
About this Structure
4jep is a 2 chain structure with sequence from Toxoplasma gondii. Full crystallographic information is available from OCA.
