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{{Seed}}
[[Image:3loc.png|left|200px]]
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{{STRUCTURE_3loc|  PDB=3loc  |  SCENE=  }}  
{{STRUCTURE_3loc|  PDB=3loc  |  SCENE=  }}  
===Crystal structure of putative transcriptional regulator ycdc===
===Crystal structure of putative transcriptional regulator ycdc===


==Function==
[[http://www.uniprot.org/uniprot/RUTR_ECOLI RUTR_ECOLI]] Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX).<ref>PMID:16540542</ref> <ref>PMID:17919280</ref> 


==About this Structure==
==About this Structure==
3LOC is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1pb6 1pb6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOC OCA].  
[[3loc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1pb6 1pb6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOC OCA].  
 
==Reference==
<references group="xtra"/><references/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Almo, S C.]]
[[Category: Almo, S C.]]
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[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Uracil]]
[[Category: Uracil]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:17:45 2010''

Revision as of 23:16, 10 April 2013

Template:STRUCTURE 3loc

Crystal structure of putative transcriptional regulator ycdc

Function

[RUTR_ECOLI] Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX).[1] [2]

About this Structure

3loc is a 4 chain structure with sequence from Escherichia coli. This structure supersedes the now removed PDB entry 1pb6. Full crystallographic information is available from OCA.

Reference

  1. ↑ Loh KD, Gyaneshwar P, Markenscoff Papadimitriou E, Fong R, Kim KS, Parales R, Zhou Z, Inwood W, Kustu S. A previously undescribed pathway for pyrimidine catabolism. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5114-9. Epub 2006 Mar 15. PMID:16540542 doi:0600521103
  2. ↑ Shimada T, Hirao K, Kori A, Yamamoto K, Ishihama A. RutR is the uracil/thymine-sensing master regulator of a set of genes for synthesis and degradation of pyrimidines. Mol Microbiol. 2007 Nov;66(3):744-57. Epub 2007 Oct 5. PMID:17919280 doi:10.1111/j.1365-2958.2007.05954.x

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