2ykd: Difference between revisions
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{{STRUCTURE_2ykd| PDB=2ykd | SCENE= }} | {{STRUCTURE_2ykd| PDB=2ykd | SCENE= }} | ||
===STRUCTURE OF THE MATRIX PROTEIN FROM HUMAN RESPIRATORY SYNCYTIAL VIRUS=== | ===STRUCTURE OF THE MATRIX PROTEIN FROM HUMAN RESPIRATORY SYNCYTIAL VIRUS=== | ||
{{ABSTRACT_PUBMED_21141948}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MATRX_HRSVA MATRX_HRSVA]] Has a crucial role in virus assembly and budding. The matrix interacts with the RNP complex and this association serves two functions: facilitate virion assembly and inhibit the viral transcriptase activity. Early in infection, M is localized to the nucleus and may inhibit host cell transcription. Later on, M can associate with lipid rafts supposely by interacting with the cytoskeleton and with the cytoplasmic tail of glycoprotein G. The binding of M to host membrane is stabilized by the surface expression of the viral glycoproteins. These interactions may allow virus formation by mediating association of the nucleocapsid with the nascent envelop.<ref>PMID:11907323</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021141948</ref><references group="xtra"/> | <ref group="xtra">PMID:021141948</ref><references group="xtra"/><references/> | ||
[[Category: Human respiratory syncytial virus]] | [[Category: Human respiratory syncytial virus]] | ||
[[Category: Beeby, A.]] | [[Category: Beeby, A.]] | ||
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[[Category: Watson, S M.D.]] | [[Category: Watson, S M.D.]] | ||
[[Category: Yeo, R P.]] | [[Category: Yeo, R P.]] | ||
[[Category: Peripheral membrane protein]] | |||
[[Category: Viral matrix protein]] | |||
[[Category: Viral protein]] | |||
[[Category: Virion]] | |||
Revision as of 23:18, 10 April 2013
STRUCTURE OF THE MATRIX PROTEIN FROM HUMAN RESPIRATORY SYNCYTIAL VIRUS
Template:ABSTRACT PUBMED 21141948
Function
[MATRX_HRSVA] Has a crucial role in virus assembly and budding. The matrix interacts with the RNP complex and this association serves two functions: facilitate virion assembly and inhibit the viral transcriptase activity. Early in infection, M is localized to the nucleus and may inhibit host cell transcription. Later on, M can associate with lipid rafts supposely by interacting with the cytoskeleton and with the cytoplasmic tail of glycoprotein G. The binding of M to host membrane is stabilized by the surface expression of the viral glycoproteins. These interactions may allow virus formation by mediating association of the nucleocapsid with the nascent envelop.[1]
About this Structure
2ykd is a 1 chain structure with sequence from Human respiratory syncytial virus. Full crystallographic information is available from OCA.
Reference
- McPhee HK, Carlisle JL, Beeby A, Money VA, Watson SM, Yeo RP, Sanderson JM. Influence of lipids on the interfacial disposition of respiratory syncytical virus matrix protein. Langmuir. 2011 Jan 4;27(1):304-11. Epub 2010 Dec 9. PMID:21141948 doi:10.1021/la104041n
