3maw: Difference between revisions

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{{Seed}}
[[Image:3maw.png|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3maw", creates the "Structure Box" on the page.
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{{STRUCTURE_3maw|  PDB=3maw  |  SCENE=  }}  
{{STRUCTURE_3maw|  PDB=3maw  |  SCENE=  }}  
===Structure of the Newcastle disease virus F protein in the post-fusion conformation===
===Structure of the Newcastle disease virus F protein in the post-fusion conformation===
{{ABSTRACT_PUBMED_20439109}}


 
==Function==
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[[http://www.uniprot.org/uniprot/FUS_NDVA FUS_NDVA]] Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with HN at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).  
The line below this paragraph, {{ABSTRACT_PUBMED_20439109}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_20439109}}


==About this Structure==
==About this Structure==
3MAW is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Newcastle_disease_virus Newcastle disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAW OCA].  
[[3maw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Newcastle_disease_virus Newcastle disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAW OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20439109</ref><references group="xtra"/>
<ref group="xtra">PMID:020439109</ref><references group="xtra"/><references/>
[[Category: Newcastle disease virus]]
[[Category: Newcastle disease virus]]
[[Category: Jardetzky, T S.]]
[[Category: Jardetzky, T S.]]
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[[Category: Paramyxovirus]]
[[Category: Paramyxovirus]]
[[Category: Viral protein]]
[[Category: Viral protein]]
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Retrieved from "https://proteopedia.org/3maw"