3maz: Difference between revisions

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{{Seed}}
[[Image:3maz.jpg|left|200px]]
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{{STRUCTURE_3maz|  PDB=3maz  |  SCENE=  }}  
{{STRUCTURE_3maz|  PDB=3maz  |  SCENE=  }}  
===Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide===
===Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide===
{{ABSTRACT_PUBMED_20442417}}


==Disease==
[[http://www.uniprot.org/uniprot/NTAL_HUMAN NTAL_HUMAN]] Williams syndrome. Note=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.<ref>PMID:11124535</ref> <ref>PMID:11003705</ref> <ref>PMID:11124535</ref> 


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_20442417}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/STAP1_HUMAN STAP1_HUMAN]] In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.<ref>PMID:10518561</ref>  [[http://www.uniprot.org/uniprot/NTAL_HUMAN NTAL_HUMAN]] Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.<ref>PMID:12486104</ref> <ref>PMID:12514734</ref> <ref>PMID:15010370</ref> 
(as it appears on PubMed at http://www.pubmed.gov), where 20442417 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20442417}}


==About this Structure==
==About this Structure==
3MAZ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAZ OCA].  
[[3maz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAZ OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20442417</ref><references group="xtra"/>
<ref group="xtra">PMID:020442417</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Huang, H.]]
[[Category: Huang, H.]]
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[[Category: Wu, C.]]
[[Category: Wu, C.]]
[[Category: Zhao, B.]]
[[Category: Zhao, B.]]
[[Category: Cytoplasm]]
[[Category: Modular domain]]
[[Category: Modular domain]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
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[[Category: Signaling protein]]
[[Category: Signaling protein]]
[[Category: Specificity]]
[[Category: Specificity]]
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Retrieved from "https://proteopedia.org/3maz"