2ehb: Difference between revisions

Line 4:

==Overview==

The plant SOS2 family of protein kinases and their interacting activators, the SOS3 family of calcium-binding proteins, function together in decoding, calcium signals elicited by different environmental stimuli. SOS2 is, activated by Ca-SOS3 and subsequently phosphorylates the ion transporter, SOS1 to bring about cellular ion homeostasis under salt stress. In, addition to possessing the kinase activity, members of the SOS2 family of, protein kinases can bind to protein phosphatase 2Cs. The crystal structure, of the binary complex of Ca-SOS3 with the C-terminal regulatory moiety of, SOS2 resolves central questions regarding the dual function of SOS2 as a, kinase and a phosphatase-binding protein. A comparison with the structure, of unbound SOS3 reveals the basis of the molecular function of this family, of kinases and their interacting calcium sensors. Furthermore, our study, suggests that the structure of the phosphatase-interaction domain of SOS2, defines a scaffold module conserved from yeast to human.

The plant SOS2 family of protein kinases and their interacting activators, the SOS3 family of calcium-binding proteins, function together in decoding calcium signals elicited by different environmental stimuli. SOS2 is activated by Ca-SOS3 and subsequently phosphorylates the ion transporter SOS1 to bring about cellular ion homeostasis under salt stress. In addition to possessing the kinase activity, members of the SOS2 family of protein kinases can bind to protein phosphatase 2Cs. The crystal structure of the binary complex of Ca-SOS3 with the C-terminal regulatory moiety of SOS2 resolves central questions regarding the dual function of SOS2 as a kinase and a phosphatase-binding protein. A comparison with the structure of unbound SOS3 reveals the basis of the molecular function of this family of kinases and their interacting calcium sensors. Furthermore, our study suggests that the structure of the phosphatase-interaction domain of SOS2 defines a scaffold module conserved from yeast to human.

==About this Structure==

Line 14:

[[Category: Non-specific serine/threonine protein kinase]]

[[Category: Protein complex]]

[[Category: Sanchez-Barrena, M.J.]]

[[Category: Sanchez-Barrena, M J.]]

[[Category: CA]]

[[Category: ca(ii) ions bound to sos3 (ef-hands 1 and 4)]]

Line 22:

[[Category: sos2 phosphatase binding domain (ppi)]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jan 23 13~~:25:13 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:10:01 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 4: / Line 4: @@
 ==Overview==
-The plant SOS2 family of protein kinases and their interacting activators, the SOS3 family of calcium-binding proteins, function together in decoding, calcium signals elicited by different environmental stimuli. SOS2 is, activated by Ca-SOS3 and subsequently phosphorylates the ion transporter, SOS1 to bring about cellular ion homeostasis under salt stress. In, addition to possessing the kinase activity, members of the SOS2 family of, protein kinases can bind to protein phosphatase 2Cs. The crystal structure, of the binary complex of Ca-SOS3 with the C-terminal regulatory moiety of, SOS2 resolves central questions regarding the dual function of SOS2 as a, kinase and a phosphatase-binding protein. A comparison with the structure, of unbound SOS3 reveals the basis of the molecular function of this family, of kinases and their interacting calcium sensors. Furthermore, our study, suggests that the structure of the phosphatase-interaction domain of SOS2, defines a scaffold module conserved from yeast to human.
+The plant SOS2 family of protein kinases and their interacting activators, the SOS3 family of calcium-binding proteins, function together in decoding calcium signals elicited by different environmental stimuli. SOS2 is activated by Ca-SOS3 and subsequently phosphorylates the ion transporter SOS1 to bring about cellular ion homeostasis under salt stress. In addition to possessing the kinase activity, members of the SOS2 family of protein kinases can bind to protein phosphatase 2Cs. The crystal structure of the binary complex of Ca-SOS3 with the C-terminal regulatory moiety of SOS2 resolves central questions regarding the dual function of SOS2 as a kinase and a phosphatase-binding protein. A comparison with the structure of unbound SOS3 reveals the basis of the molecular function of this family of kinases and their interacting calcium sensors. Furthermore, our study suggests that the structure of the phosphatase-interaction domain of SOS2 defines a scaffold module conserved from yeast to human.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Non-specific serine/threonine protein kinase]]
 [[Category: Protein complex]]
-[[Category: Sanchez-Barrena, M.J.]]
+[[Category: Sanchez-Barrena, M J.]]
 [[Category: CA]]
 [[Category: ca(ii) ions bound to sos3 (ef-hands 1 and 4)]]
@@ Line 22: / Line 22: @@
 [[Category: sos2 phosphatase binding domain (ppi)]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:25:13 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:10:01 2008''