3m62: Difference between revisions

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{{Seed}}
[[Image:3m62.png|left|200px]]
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{{STRUCTURE_3m62|  PDB=3m62  |  SCENE=  }}  
{{STRUCTURE_3m62|  PDB=3m62  |  SCENE=  }}  
===Crystal structure of Ufd2 in complex with the ubiquitin-like (UBL) domain of Rad23===
===Crystal structure of Ufd2 in complex with the ubiquitin-like (UBL) domain of Rad23===
{{ABSTRACT_PUBMED_20427284}}


 
==Function==
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[[http://www.uniprot.org/uniprot/UFD2_YEAST UFD2_YEAST]] E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly. Binds to CDC48 and elongates mono- and diubiquitinated ERAD substrates presented by the UFD1-NPL4-CDC48/p97 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties. Delivers these polyubiquitinated substrates to RAD23 and DSK2, which target them to the proteasome. Has E3 ubiquitin-protein ligase activity, accepting ubiquitin from its cognate E2 ubiquitin-conjugating enzyme UBC4. Enhances ubiquitination at 'Lys-48', but not at 'Lys-29' of the Ub moiety. Promotes ubiquitin chain elongation at 'Lys-48' on the DOA10 substrate PEX29. Also involved in the proteolytic processing of the ER-bound transcription factor SPT23.<ref>PMID:10089879</ref> <ref>PMID:15240124</ref> <ref>PMID:15652483</ref> <ref>PMID:18191224</ref> <ref>PMID:20159987</ref>  [[http://www.uniprot.org/uniprot/RAD23_YEAST RAD23_YEAST]] Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes.
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{{ABSTRACT_PUBMED_20427284}}


==About this Structure==
==About this Structure==
3M62 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M62 OCA].  
[[3m62]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M62 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20427284</ref><references group="xtra"/>
<ref group="xtra">PMID:020427284</ref><references group="xtra"/><references/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Haenzelmann, P.]]
[[Category: Haenzelmann, P.]]
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[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Ubl conjugation pathway]]
[[Category: Ubl conjugation pathway]]
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Retrieved from "https://proteopedia.org/3m62"