3lsw: Difference between revisions
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{{STRUCTURE_3lsw| PDB=3lsw | SCENE= }} | {{STRUCTURE_3lsw| PDB=3lsw | SCENE= }} | ||
===Aniracetam bound to the ligand binding domain of GluA3=== | ===Aniracetam bound to the ligand binding domain of GluA3=== | ||
{{ABSTRACT_PUBMED_20163115}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GRIA3_RAT GRIA3_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[3lsw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LSW OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020163115</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Ahmed, A H.]] | [[Category: Ahmed, A H.]] | ||
[[Category: Oswald, R E.]] | [[Category: Oswald, R E.]] | ||
| Line 35: | Line 22: | ||
[[Category: S1s2]] | [[Category: S1s2]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 23:32, 10 April 2013
Aniracetam bound to the ligand binding domain of GluA3
Template:ABSTRACT PUBMED 20163115
Function
[GRIA3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
About this Structure
3lsw is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Ahmed AH, Oswald RE. Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors. J Med Chem. 2010 Mar 11;53(5):2197-203. PMID:20163115 doi:10.1021/jm901905j
