3m4t: Difference between revisions

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~~[[Image:3m4t.png|left|200px]]~~

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===Crystal structure of the BTB domain from Kaiso/ZBTB33, form I===

==Function==

[[http://www.uniprot.org/uniprot/KAISO_HUMAN KAISO_HUMAN]] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.<ref>PMID:11445535</ref> <ref>PMID:14527417</ref> <ref>PMID:15548582</ref> <ref>PMID:15817151</ref>

==About this Structure==

[[3m4t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4T OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Chen, L.]]

[[Category: Prive, G G.]]

[[Category: Stogios, P J.]]

[[Category: Activator]]

[[Category: Btb domain]]

[[Category: Btb/poz domain]]

[[Category: Dna-binding]]

[[Category: Kaiso]]

[[Category: Metal-binding]]

[[Category: Nucleus]]

[[Category: Oligomeriation]]

[[Category: Phosphoprotein]]

[[Category: Poz domain]]

[[Category: Protein-protein interaction domain]]

[[Category: Repressor]]

[[Category: Transcription]]

[[Category: Transcription regulation]]

[[Category: Transcriptional regulator kaiso]]

[[Category: Wnt signaling pathway]]

[[Category: Zbtb33]]

[[Category: Zinc finger and btb domain-containing protein 33]]

[[Category: Zinc-finger]]

[[Category: Zinc-finger protein]]

[[Category: Znf348]]

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-[[Image:3m4t.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3m4t", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3m4t|  PDB=3m4t  |  SCENE=  }}
 ===Crystal structure of the BTB domain from Kaiso/ZBTB33, form I===
+==Function==
+[[http://www.uniprot.org/uniprot/KAISO_HUMAN KAISO_HUMAN]] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.<ref>PMID:11445535</ref> <ref>PMID:14527417</ref> <ref>PMID:15548582</ref> <ref>PMID:15817151</ref>
 ==About this Structure==
 [[3m4t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4T OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Chen, L.]]
 [[Category: Prive, G G.]]
 [[Category: Stogios, P J.]]
+[[Category: Activator]]
+[[Category: Btb domain]]
+[[Category: Btb/poz domain]]
+[[Category: Dna-binding]]
+[[Category: Kaiso]]
+[[Category: Metal-binding]]
+[[Category: Nucleus]]
+[[Category: Oligomeriation]]
+[[Category: Phosphoprotein]]
+[[Category: Poz domain]]
+[[Category: Protein-protein interaction domain]]
+[[Category: Repressor]]
+[[Category: Transcription]]
+[[Category: Transcription regulation]]
+[[Category: Transcriptional regulator kaiso]]
+[[Category: Wnt signaling pathway]]
+[[Category: Zbtb33]]
+[[Category: Zinc finger and btb domain-containing protein 33]]
+[[Category: Zinc-finger]]
+[[Category: Zinc-finger protein]]
+[[Category: Znf348]]