User:Michael Roberts/BIOL115 CaM: Difference between revisions
New page: left|200px Calmodulin tutorial test <Structure load='1CLL' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' ... |
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[[Image:1ckk.png|left|200px]] | [[Image:1ckk.png|left|200px]] | ||
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Sequence and structure of EF hands''' | |||
Calmodulin | The EF hand motif is present in a many proteins and it commonly bestows the ability to bind Ca2+ ions. It was first identified in parvalbumin, a muscle protein. Here we will have a look at the Ca2+-binding protein calmodulin, which possesses four EF hands. Calmodulin and its isoform, troponinC, are important intracellular Ca2+-binding proteins. | ||
The structure on the right, obtained by X-ray crystallography, represents the Ca2+-binding protein calmodulin. It has a dumbell-shaped structure with two identical lobes connected by a central alpha-helix. Each lobe comprises three a helices joined by loops. A helix-loop-helix motif forms the basis of each EF hand. | |||
<Structure load='1CLL' size='500' frame='true' align='right' caption=' | Click on the 'green links' below to examine this molecule in more detail. | ||
<Structure load='1CLL' size='500' frame='true' align='right' caption='Human calmodulin' scene='Insert optional scene name here' /> | |||
Let us color the two main forms of regular <scene name='Sandbox_LUBIOL115/Structure_plus_ca/1'>secondary structure</scene> in this protein. Alpha helix appears in red, beta sheet in yellow. | Let us color the two main forms of regular <scene name='Sandbox_LUBIOL115/Structure_plus_ca/1'>secondary structure</scene> in this protein. Alpha helix appears in red, beta sheet in yellow. | ||
Revision as of 23:29, 11 April 2013
Sequence and structure of EF hands
The EF hand motif is present in a many proteins and it commonly bestows the ability to bind Ca2+ ions. It was first identified in parvalbumin, a muscle protein. Here we will have a look at the Ca2+-binding protein calmodulin, which possesses four EF hands. Calmodulin and its isoform, troponinC, are important intracellular Ca2+-binding proteins. The structure on the right, obtained by X-ray crystallography, represents the Ca2+-binding protein calmodulin. It has a dumbell-shaped structure with two identical lobes connected by a central alpha-helix. Each lobe comprises three a helices joined by loops. A helix-loop-helix motif forms the basis of each EF hand.
Click on the 'green links' below to examine this molecule in more detail.
|
Let us color the two main forms of regular secondary structure in this protein. Alpha helix appears in red, beta sheet in yellow.
Alpha Helices, Beta Strands , Turns.
