2ca8: Difference between revisions

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[[Image:2ca8.png|left|200px]]
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{{STRUCTURE_2ca8|  PDB=2ca8  |  SCENE=  }}  
{{STRUCTURE_2ca8|  PDB=2ca8  |  SCENE=  }}  
===Structure of Sh28GST in complex with GSH at pH 6.0===
{{ABSTRACT_PUBMED_16777141}}


===Stucture of Sh28GST in complex with GSH at pH 6.0===
==Function==
 
[[http://www.uniprot.org/uniprot/GST28_SCHBO GST28_SCHBO]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.  GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.  
 
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{{ABSTRACT_PUBMED_16777141}}


==About this Structure==
==About this Structure==
[[2ca8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA].  
[[2ca8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA].  
==See Also==
*[[Glutathione S-transferase|Glutathione S-transferase]]


==Reference==
==Reference==
<ref group="xtra">PMID:016777141</ref><references group="xtra"/>
<ref group="xtra">PMID:016777141</ref><references group="xtra"/><references/>
[[Category: Glutathione transferase]]
[[Category: Glutathione transferase]]
[[Category: Schistosoma haematobium]]
[[Category: Schistosoma haematobium]]

Revision as of 19:22, 17 April 2013

Template:STRUCTURE 2ca8

Structure of Sh28GST in complex with GSH at pH 6.0

Template:ABSTRACT PUBMED 16777141

Function

[GST28_SCHBO] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.

About this Structure

2ca8 is a 1 chain structure with sequence from Schistosoma haematobium. Full crystallographic information is available from OCA.

See Also

Reference

  1. Baiocco P, Gourlay LJ, Angelucci F, Fontaine J, Herve M, Miele AE, Trottein F, Brunori M, Bellelli A. Probing the mechanism of GSH activation in Schistosoma haematobium glutathione-S-transferase by site-directed mutagenesis and X-ray crystallography. J Mol Biol. 2006 Jul 14;360(3):678-89. Epub 2006 Jun 2. PMID:16777141 doi:10.1016/j.jmb.2006.05.040

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