4iyp: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===structure of the nPP2Ac-alpha4 complex===

~~The~~ entry ~~4iyp~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/IGBP1_HUMAN IGBP1_HUMAN]] Agenesis of the corpus callosum - intellectual deficit - coloboma - micrognathia. Defects in IGBP1 are the cause of mental retardation syndromic X-linked type 28 (MRXS28) [MIM:[http://omim.org/entry/300472 300472]]; also known as agenesis of the corpus callosum with mental retardation, ocular coloboma and micrognathia. A syndrome that is characterized by coloboma of the iris and optic nerve, severe retrognathia, intellectual deficit, and agenesis of the corpus callosum.<ref>PMID:14556245</ref>

~~Authors~~: Li, J., ~~Stanevich~~, V.~~, Satyshur, K~~.A.~~, Xing, Y~~.

==Function==

[[http://www.uniprot.org/uniprot/IGBP1_HUMAN IGBP1_HUMAN]] Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits.<ref>PMID:19818709</ref> [[http://www.uniprot.org/uniprot/PP2AA_HUMAN PP2AA_HUMAN]] PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.<ref>PMID:9920888</ref> <ref>PMID:10801873</ref> <ref>PMID:22613722</ref>

~~Description~~: ~~structure of the nPP2Ac~~-~~alpha4 complex~~

==About this Structure==

[[4iyp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYP OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Phosphoprotein phosphatase]]

[[Category: Li, J.]]

[[Category: Satyshur, K A.]]

[[Category: Stanevich, V.]]

[[Category: Xing, Y.]]

[[Category: Alpha4]]

[[Category: Helix motif]]

[[Category: Latency]]

[[Category: Pp2a]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4iyp|  PDB=4iyp  |  SCENE=  }}
+===structure of the nPP2Ac-alpha4 complex===
-The entry 4iyp is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/IGBP1_HUMAN IGBP1_HUMAN]] Agenesis of the corpus callosum - intellectual deficit - coloboma - micrognathia. Defects in IGBP1 are the cause of mental retardation syndromic X-linked type 28 (MRXS28) [MIM:[http://omim.org/entry/300472 300472]]; also known as agenesis of the corpus callosum with mental retardation, ocular coloboma and micrognathia. A syndrome that is characterized by coloboma of the iris and optic nerve, severe retrognathia, intellectual deficit, and agenesis of the corpus callosum.<ref>PMID:14556245</ref>
-Authors: Li, J., Stanevich, V., Satyshur, K.A., Xing, Y.
+==Function==
+[[http://www.uniprot.org/uniprot/IGBP1_HUMAN IGBP1_HUMAN]] Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits.<ref>PMID:19818709</ref>  [[http://www.uniprot.org/uniprot/PP2AA_HUMAN PP2AA_HUMAN]] PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.<ref>PMID:9920888</ref> <ref>PMID:10801873</ref> <ref>PMID:22613722</ref>
-Description: structure of the nPP2Ac-alpha4 complex
+==About this Structure==
+[[4iyp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYP OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Phosphoprotein phosphatase]]
+[[Category: Li, J.]]
+[[Category: Satyshur, K A.]]
+[[Category: Stanevich, V.]]
+[[Category: Xing, Y.]]
+[[Category: Alpha4]]
+[[Category: Helix motif]]
+[[Category: Latency]]
+[[Category: Pp2a]]
+[[Category: Signaling protein]]