2xoc: Difference between revisions

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~~[[Image:2xoc.png|left|200px]]~~

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===C-TERMINAL CYSTEINE-RICH DOMAIN OF HUMAN CHFR BOUND TO MADPR===

==Function==

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[[http://www.uniprot.org/uniprot/CHFR_HUMAN CHFR_HUMAN]] E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.<ref>PMID:10935642</ref> <ref>PMID:11807090</ref> <ref>PMID:11912157</ref> <ref>PMID:14562038</ref> <ref>PMID:14694445</ref> <ref>PMID:18172500</ref> <ref>PMID:19182791</ref>

~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_20880844}}~~, ~~adds~~ the ~~Publication Abstract~~ to the ~~page~~

(~~as it appears on PubMed~~ at ~~http~~://~~www.pubmed.gov), where 20880844 is the PubMed ID number.~~

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~~{{ABSTRACT_PUBMED_20880844}}~~

==About this Structure==

[[2xoc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XOC OCA].

==See Also==

*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]

==Reference==

[[Category: Homo sapiens]]

[[Category: Bayliss, R.]]

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-[[Image:2xoc.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_2xoc", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_2xoc|  PDB=2xoc  |  SCENE=  }}
 ===C-TERMINAL CYSTEINE-RICH DOMAIN OF HUMAN CHFR BOUND TO MADPR===
+{{ABSTRACT_PUBMED_20880844}}
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/CHFR_HUMAN CHFR_HUMAN]] E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.<ref>PMID:10935642</ref> <ref>PMID:11807090</ref> <ref>PMID:11912157</ref> <ref>PMID:14562038</ref> <ref>PMID:14694445</ref> <ref>PMID:18172500</ref> <ref>PMID:19182791</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_20880844}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 20880844 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_20880844}}
 ==About this Structure==
 [[2xoc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XOC OCA].
+==See Also==
+*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
 ==Reference==
-<ref group="xtra">PMID:020880844</ref><references group="xtra"/>
+<ref group="xtra">PMID:020880844</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Bayliss, R.]]