3msx: Difference between revisions

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~~[[Image:3msx.jpg|left|200px]]~~

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===Crystal structure of RhoA.GDP.MgF3 in complex with GAP domain of ArhGAP20===

===~~Crystal structure~~ of ~~RhoA~~.~~GDP~~.~~MgF3 in complex with GAP domain of ArhGAP20===~~

==Disease==

[[http://www.uniprot.org/uniprot/RHG20_HUMAN RHG20_HUMAN]] Note=A chromosomal aberration involving ARHGAP20 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with BRWD3 does not result in fusion transcripts but disrupts both genes.

==Function==

[[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref> [[http://www.uniprot.org/uniprot/RHG20_HUMAN RHG20_HUMAN]] GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity).

==About this Structure==

[[3msx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MSX OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Small monomeric GTPase]]

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[[Category: Derewenda, Z S.]]

[[Category: Utepbergenov, D.]]

[[Category: Gtpase]]

[[Category: Protein binding]]

[[Category: Protein-proten complex]]

[[Category: Transition state]]

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@@ Line 1: / Line 1: @@
-[[Image:3msx.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3msx", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3msx|  PDB=3msx  |  SCENE=  }}
+===Crystal structure of RhoA.GDP.MgF3 in complex with GAP domain of ArhGAP20===
-===Crystal structure of RhoA.GDP.MgF3 in complex with GAP domain of ArhGAP20===
+==Disease==
+[[http://www.uniprot.org/uniprot/RHG20_HUMAN RHG20_HUMAN]] Note=A chromosomal aberration involving ARHGAP20 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with BRWD3 does not result in fusion transcripts but disrupts both genes.
+==Function==
+[[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>  [[http://www.uniprot.org/uniprot/RHG20_HUMAN RHG20_HUMAN]] GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity).
 ==About this Structure==
 [[3msx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MSX OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Small monomeric GTPase]]
@@ Line 20: / Line 19: @@
 [[Category: Derewenda, Z S.]]
 [[Category: Utepbergenov, D.]]
+[[Category: Gtpase]]
+[[Category: Protein binding]]
+[[Category: Protein-proten complex]]
+[[Category: Transition state]]