3n2n: Difference between revisions

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[[Image:3n2n.jpg|left|200px]]
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{{STRUCTURE_3n2n|  PDB=3n2n  |  SCENE=  }}  
{{STRUCTURE_3n2n|  PDB=3n2n  |  SCENE=  }}  
===The Crystal Structure of Tumor Endothelial Marker 8 (TEM8) extracellular domain===
===The Crystal Structure of Tumor Endothelial Marker 8 (TEM8) extracellular domain===
{{ABSTRACT_PUBMED_20585457}}


==Disease==
[[http://www.uniprot.org/uniprot/ANTR1_HUMAN ANTR1_HUMAN]] Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:[http://omim.org/entry/602089 602089]]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.<ref>PMID:18931684</ref> 


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_20585457}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/ANTR1_HUMAN ANTR1_HUMAN]] Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.<ref>PMID:15777794</ref> <ref>PMID:16762926</ref>
(as it appears on PubMed at http://www.pubmed.gov), where 20585457 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20585457}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:20585457</ref><references group="xtra"/>
<ref group="xtra">PMID:020585457</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fu, S.]]
[[Category: Fu, S.]]
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[[Category: Tong, X H.]]
[[Category: Tong, X H.]]
[[Category: Wu, Y.]]
[[Category: Wu, Y.]]
[[Category: Anthrax]]
[[Category: Rossmann fold]]
[[Category: Toxin receptor]]
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