3mh4: Difference between revisions

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~~[[Image:3mh4.jpg|left|200px]]~~

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===HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular cues===

==Function==

[[http://www.uniprot.org/uniprot/DEGP_ECOLI DEGP_ECOLI]] DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP).<ref>PMID:2180903</ref> <ref>PMID:8830688</ref> <ref>PMID:10319814</ref> <ref>PMID:18505836</ref> <ref>PMID:12730160</ref> <ref>PMID:18496527</ref>

==About this Structure==

~~3MH4~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MH4 OCA].

[[3mh4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MH4 OCA].

==Reference==

[[Category: Escherichia coli]]

[[Category: Clausen, T.]]

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[[Category: Hydrolase]]

[[Category: Protease]]

~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:48:37 2010''~~

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-{{Seed}}
-[[Image:3mh4.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3mh4", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3mh4|  PDB=3mh4  |  SCENE=  }}
 ===HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular cues===
+{{ABSTRACT_PUBMED_020581825}}
+==Function==
+[[http://www.uniprot.org/uniprot/DEGP_ECOLI DEGP_ECOLI]] DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP).<ref>PMID:2180903</ref> <ref>PMID:8830688</ref> <ref>PMID:10319814</ref> <ref>PMID:18505836</ref> <ref>PMID:12730160</ref> <ref>PMID:18496527</ref>
 ==About this Structure==
-MH4 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MH4 OCA].
+[[3mh4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MH4 OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Escherichia coli]]
 [[Category: Clausen, T.]]
@@ Line 24: / Line 20: @@
 [[Category: Hydrolase]]
 [[Category: Protease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:48:37 2010''