3n7o: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
m Protected "3n7o" [edit=sysop:move=sysop] |
(No difference)
| |
Revision as of 21:15, 17 April 2013
X-ray structure of human chymase in complex with small molecule inhibitor.
Template:ABSTRACT PUBMED 20599788
Function
[CMA1_HUMAN] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
About this Structure
3n7o is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kervinen J, Crysler C, Bayoumy S, Abad MC, Spurlino J, Deckman I, Greco MN, Maryanoff BE, de Garavilla L. Potency variation of small-molecule chymase inhibitors across species. Biochem Pharmacol. 2010 Oct 1;80(7):1033-41. Epub 2010 Jun 23. PMID:20599788 doi:10.1016/j.bcp.2010.06.014
