Methotrexate: Difference between revisions

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[[Methotrexate]], formerly known as amethopterin, is a drug that is used in the competitive inhibition of [[Dihydrofolate reductase]], resulting in decreased synthesis of dTTP and diminished cellular replication.  The antimetabolic nature of methotrexate is most effective against the most rapidly dividing cells, making this drug useful in [[Cancer]] [[Pharmaceutical Drugs|treatment]], and various autoimmune diseases<ref>Methotrexate. (n.d.). UW Department of Orthopaedics and Sports Medicine - Patient Care. Retrieved March 10, 2011, from http://www.orthop.washington.edu/PatientCare/OurServices/Arthritis/Articles/Methotrexate.aspx </ref>.
[[Methotrexate]], formerly known as amethopterin, is a drug that is used in the competitive inhibition of [[Dihydrofolate reductase]], resulting in decreased synthesis of dTTP and diminished cellular replication.  The antimetabolic nature of methotrexate is most effective against the most rapidly dividing cells, making this drug useful in [[Cancer]] [[Pharmaceutical Drugs|treatment]], and various autoimmune diseases<ref>Methotrexate. (n.d.). UW Department of Orthopaedics and Sports Medicine - Patient Care. Retrieved March 10, 2011, from http://www.orthop.washington.edu/PatientCare/OurServices/Arthritis/Articles/Methotrexate.aspx </ref>.


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