4b94: Difference between revisions
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{{STRUCTURE_4b94| PDB=4b94 | SCENE= }} | |||
===Crystal structure of human Mps1 TPR domain=== | |||
{{ABSTRACT_PUBMED_23569217}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | |||
==About this Structure== | |||
[[4b94]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B94 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Dual-specificity kinase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Castelmur, E von.]] | |||
[[Category: Littler, D.]] | |||
[[Category: Marco, V De.]] | |||
[[Category: Perrakis, A.]] | |||
[[Category: Kinetochore]] | |||
[[Category: Mitosis]] | |||
[[Category: Transferase]] | |||
Revision as of 11:17, 24 April 2013
Crystal structure of human Mps1 TPR domain
Template:ABSTRACT PUBMED 23569217
Function
[TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.[1]
About this Structure
4b94 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 2008 Jan 25;132(2):233-46. doi: 10.1016/j.cell.2007.11.046. PMID:18243099 doi:10.1016/j.cell.2007.11.046
