2f3k: Difference between revisions
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==Overview== | ==Overview== | ||
In our previous crystallographic studies of human immunodeficiency virus | In our previous crystallographic studies of human immunodeficiency virus type 1 (HIV-1) protease-substrate complexes, we described a conserved "envelope" that appears to be important for substrate recognition and the selection of drug-resistant mutations. In this study, the complex of HIV-1 protease with the inhibitor RO1 was determined and comparison with the substrate envelope provides a rationale for mutational patterns. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Cammack, N.]] | [[Category: Cammack, N.]] | ||
[[Category: Heilek-Snyder, G.]] | [[Category: Heilek-Snyder, G.]] | ||
[[Category: King, N | [[Category: King, N M.]] | ||
[[Category: Nalivaika, E | [[Category: Nalivaika, E A.]] | ||
[[Category: Prabu-Jeyabalan, M.]] | [[Category: Prabu-Jeyabalan, M.]] | ||
[[Category: Schiffer, C | [[Category: Schiffer, C A.]] | ||
[[Category: PO4]] | [[Category: PO4]] | ||
[[Category: RO1]] | [[Category: RO1]] | ||
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[[Category: substrate envelope]] | [[Category: substrate envelope]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:17:23 2008'' | ||
