3zlr: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_3zlr|  PDB=3zlr  |  SCENE=  }}
+===Crystal structure of Bcl-xL in complex with inhibitor (WEHI-539).===
-The entry 3zlr is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>   Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
-Authors: Czabotar, P.E., Lessene, G.L., Smith, B.J., Colman, P.M.
+==About this Structure==
+[[3zlr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZLR OCA].
-Description: Crystal structure of Bcl-xL in complex with inhibitor (WEHI-539).
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Colman, P M.]]
+[[Category: Czabotar, P E.]]
+[[Category: Lessene, G L.]]
+[[Category: Smith, B J.]]
+[[Category: Apoptosis]]
+[[Category: Inhibitor]]

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