4i3q: Difference between revisions
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{{STRUCTURE_4i3q| PDB=4i3q | SCENE= }} | |||
===Crystal structure of human CYP3A4 coordinated to a water molecule=== | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref> | |||
==About this Structure== | |||
[[4i3q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I3Q OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Poulos, T L.]] | |||
[[Category: Sevrioukova, I F.]] | |||
[[Category: Cytochrome b5]] | |||
[[Category: Cytochrome p450]] | |||
[[Category: Cytochrome p450 reductase]] | |||
[[Category: Endoplasmic reticulum]] | |||
[[Category: Hemoprotein]] | |||
[[Category: Monooxygenase]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 11:29, 24 April 2013
Crystal structure of human CYP3A4 coordinated to a water molecule
Function
[CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.[1]
About this Structure
4i3q is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
