3frv: Difference between revisions

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{{Seed}}
[[Image:3frv.jpg|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3frv", creates the "Structure Box" on the page.
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{{STRUCTURE_3frv|  PDB=3frv  |  SCENE=  }}  
{{STRUCTURE_3frv|  PDB=3frv  |  SCENE=  }}  
===Structure of Human CHMP3 (residues 1-150)===
===Structure of Human CHMP3 (residues 1-150)===
{{ABSTRACT_PUBMED_19525971}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/CHMP3_HUMAN CHMP3_HUMAN]] Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.<ref>PMID:15707591</ref> <ref>PMID:17331679</ref> <ref>PMID:14505570</ref> <ref>PMID:18076377</ref> <ref>PMID:16740483</ref> 
The line below this paragraph, {{ABSTRACT_PUBMED_19525971}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_19525971}}


==About this Structure==
==About this Structure==
3FRV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FRV OCA].  
[[3frv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FRV OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:19525971</ref><references group="xtra"/>
<ref group="xtra">PMID:019525971</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hill, C P.]]
[[Category: Hill, C P.]]
Line 30: Line 17:
[[Category: Sundquist, W I.]]
[[Category: Sundquist, W I.]]
[[Category: Chmp]]
[[Category: Chmp]]
[[Category: Coiled coil]]
[[Category: Cytoplasm]]
[[Category: Escrt]]
[[Category: Escrt]]
[[Category: Escrt-iii]]
[[Category: Escrt-iii]]
Line 41: Line 26:
[[Category: Protein transport]]
[[Category: Protein transport]]
[[Category: Transport]]
[[Category: Transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  1 09:14:46 2009''
Retrieved from "https://proteopedia.org/3frv"