3o4r: Difference between revisions
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{{STRUCTURE_3o4r| PDB=3o4r | SCENE= }} | {{STRUCTURE_3o4r| PDB=3o4r | SCENE= }} | ||
===Crystal Structure of Human Dehydrogenase/Reductase (SDR family) member 4 (DHRS4)=== | ===Crystal Structure of Human Dehydrogenase/Reductase (SDR family) member 4 (DHRS4)=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/DHRS4_HUMAN DHRS4_HUMAN]] Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[3o4r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4R OCA]. | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
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[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: Structural genomics consortium]] | [[Category: Structural genomics consortium]] | ||
Revision as of 11:51, 24 April 2013
Crystal Structure of Human Dehydrogenase/Reductase (SDR family) member 4 (DHRS4)
Function
[DHRS4_HUMAN] Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
About this Structure
3o4r is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
