3ng2: Difference between revisions

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{{Seed}}
[[Image:3ng2.jpg|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3ng2", creates the "Structure Box" on the page.
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{{STRUCTURE_3ng2|  PDB=3ng2  |  SCENE=  }}  
{{STRUCTURE_3ng2|  PDB=3ng2  |  SCENE=  }}  
===Crystal structure of the RNF4 ring domain dimer===
===Crystal structure of the RNF4 ring domain dimer===
{{ABSTRACT_PUBMED_20681948}}


 
==Function==
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[[http://www.uniprot.org/uniprot/RNF4_RAT RNF4_RAT]] E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.<ref>PMID:9710597</ref> <ref>PMID:11319220</ref> <ref>PMID:14987998</ref> <ref>PMID:15707587</ref> <ref>PMID:18408734</ref> <ref>PMID:20943951</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_20681948}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 20681948 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20681948}}


==About this Structure==
==About this Structure==
3NG2 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NG2 OCA].  
[[3ng2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NG2 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20681948</ref><references group="xtra"/>
<ref group="xtra">PMID:020681948</ref><references group="xtra"/><references/>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Day, C L.]]
[[Category: Day, C L.]]
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[[Category: Ubiquitylation]]
[[Category: Ubiquitylation]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct  6 06:06:39 2010''
Retrieved from "https://proteopedia.org/3ng2"