3nyn: Difference between revisions

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~~[[Image:3nyn.png|left|200px]]~~

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===Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with Sangivamycin===

==Function==

~~<!--~~

[[http://www.uniprot.org/uniprot/GRK6_HUMAN GRK6_HUMAN]] Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).<ref>PMID:19801552</ref> <ref>PMID:20048153</ref>

~~The line below this paragraph, {{ABSTRACT_PUBMED_20729810}}, adds the Publication Abstract to the page~~

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 20729810~~ is ~~the PubMed ID number~~.

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~~{{ABSTRACT_PUBMED_20729810}}~~

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Singh, P.]]

[[Category: Tesmer, J J.G.]]

[[Category: G protein-coupled receptor kinase]]

[[Category: Grk]]

[[Category: Kinase]]

[[Category: Rgs homology domain]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-[[Image:3nyn.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3nyn", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3nyn|  PDB=3nyn  |  SCENE=  }}
 ===Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with Sangivamycin===
+{{ABSTRACT_PUBMED_20729810}}
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/GRK6_HUMAN GRK6_HUMAN]] Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).<ref>PMID:19801552</ref> <ref>PMID:20048153</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_20729810}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 20729810 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_20729810}}
 ==About this Structure==
@@ Line 22: / Line 10: @@
 ==Reference==
-<ref group="xtra">PMID:20729810</ref><references group="xtra"/>
+<ref group="xtra">PMID:020729810</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Singh, P.]]
 [[Category: Tesmer, J J.G.]]
+[[Category: G protein-coupled receptor kinase]]
+[[Category: Grk]]
+[[Category: Kinase]]
+[[Category: Rgs homology domain]]
+[[Category: Transferase]]